Thrombocytopenia following implantation of different types of bioprosthetic aortic valves in severe aortic valve stenosis replacement

Abstract Aim The use of bioprosthetic valves in the surgical aortic valve replacement (SAVR) or transcatheter implantation (TAVI) severe stenosis has been associated with post-implantation thrombocytopenia, usually reversible and rarely combined bleeding events. purpose this study was to compare grade thrombocytopenia presence events following valves, where either surgery (Solo, Perceval, Trifecta) method (self-expandable TAVI) followed. Methods 89 patients were included study. All underwent SAVR TAVI. In each group 3 different types used [59 group: Solo (14), Perceval (27), Trifecta (18), 30 TAVI Evolut R (10), Portico (15), Acurate (5)]. had normal slightly reduced platelet count at baseline. Patients previously receiving anticoagulants, a primary blood disorder affecting number platelets, as well post-surgery complication that could affect platelets (e.g., HIT syndrome, etc.) excluded from Blood samples taken morning before intervention every during first week follow-up. Platelet values after compared paired t-test (SPSS V21.0, Inc., Chicago, IL, USA), while reduction between 4 independent t-test. P-values <0.05 considered significant. Results Mean age 76.8±5.1 years. There no statistically significant difference 2 groups concerning baseline characteristics administered anticoagulants. Statistically observed all [Solo: 136±80x103/μl (p=0.009), Perceval: 129±75x103/μl (p<0.001), Trifecta: 74±32x103/μl (p<0.001, TAVI: 60±103μl)]. (p=0.85) (p=0.053), but case group, noted (p=0.047). A both demonstrated (p=0.040) regarding reduction. occurrence any major (3.3%) presented mild disorders (1 patient epistaxis hematuria). Conclusion Both methods, implanted, post-implantation. This linked procedure due endothelial damage, shear stress injury, inflammation-related consumption, not clinically Funding Acknowledgement Type funding sources: None.